Scholarly Achievements

Original Papers

  1. Hanafusa, N., Satonaka, H., Doi, K., Yatomi, Y., Noiri, E., and Fujita, T. Platelet-derived microparticles are removed by a membrane plasma separator. ASAIO J. 56: 323-325, 2010.
  2. Hangaishi, A., Takahashi, T., Masuda, A., Okada, S., Kandabashi, K., and Kurokawa, M. Rituximab therapy for refractory immune thrombocytopenic purpura in elder patients. Int. J. Hematol. 91: 336-7, 2010.
  3. Ikeda, H., Ohkawa, R., Watanabe, N., Nakamura, K., Kume, Y., Nakagawa, H., Yoshida, H., Okubo, S., Yokota, H., Tomiya, T., Inoue, Y., Nishikawa, T., Ohtomo, N., Tanoue, Y., Koike, K., and Yatomi, Y. Plasma concentration of bioactive lipid mediator sphingosine 1- phosphate is reduced in patients with chronic hepatitis C. Clin. Chim. Acta. 411: 765-770, 2010.
  4. Imasawa, T., Kitamura, H., Ohkawa, R., Satoh, Y., Miyashita, A., and Yatomi, Y. Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy. Exp. Toxicol. Pathol. 62: 53-60, 2010.
  5. Imasawa, T., Koike, K., Ishii, I., Chun, J., and Yatomi, Y. Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells. Biochem. Biophys. Res. Commun. 392: 207-11, 2010.
  6. Kato, Y., Araki, N., Ohkubo, T., Asano, Y., Furuya, D., Hattori, K., Simazu, T., Yamazato, M., Nagoya, H., Ito, Y., Shimosawa, T., Fujita, T., and Shimazu, K. Effects of adrenoemdullin on nitric oxide production during forebrain ischemia and reperfusion in mice. Cerebral Blood Flow and Metabolism. 21: 1-6, 2010.
  7. Koike, Y., Miyazaki, K., Higashihara, M., Kimura, E., Jona, M., Uchihashi, K., Masuda, A., Kandabashi, K., Kurokawa, M., and Yatomi, Y. Clinical significance of detection of immature platelets: comparison between percentage of reticulated platelets as detected by flow cytometry and immature platelet fraction as detected by automated measurement. Eur. J. Haematol. 84: 183-4, 2010.
  8. Kusakabe, M., Kutomi, T., Watanabe, K., Emoto, N., Aki, N., Kage, H., Hamano, E., Kitagawa, H., Nagase, T., Sano, A., Yoshida, Y., Fukami, T., Murakawa, T., Nakajima, J., Takamoto, S., Ota, S., Fukayama, M., Yatomi, Y., Ohishi, N., and Takai, D. Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches. Int. J. Cancer 126: 1895-902, 2010.
  9. Nakamura, K., Igarashi, K., Ohkawa, R., Saiki, N., Nagasaki, M., Uno, K., Hayashi, N., Sawada, T., Syukuya, K., Yokota, H., Arai, H., Ikeda, H., Aoki, J., and Yatomi, Y. A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A(1) in human serum samples. Clin. Chim. Acta 411: 1090-1094, 2010.
  10. Ogiso, H., Nakamura, K., Yatomi, Y., Shimizu, T., and Taguchi, R. Liquid chromatography/mass spectrometry analysis revealing preferential occurrence of non-arachidonate-containing phosphatidylinositol bisphosphate species in nuclei and changes in their levels during cell cycle. Rapid Commun. Mass Spectrom. 24: 436-442, 2010.
  11. Ohtomo, N., Tomiya, T., Tanoue, Y., Inoue, Y., Nishikawa, T., Ikeda, H., Seyama, Y., Kokudo, N., Shibahara, J., Fukayama, M., Koike, K., Shirataki, H., and Fujiwara, K.Expression of ƒ¿-taxilin in hepatocellular carcinoma correlates with growth activity and malignant potential of the tumor. Int. J. Oncol. 37: 1417-1423, 2010.
  12. Okano, T., Terao, Y., Furubayashi, T., Yugeta, A., Hanajima, R., and Ugawa, Y. The effect of electromagnetic field emitted by a mobile phone on the inhibitory control of saccades. Clin Neurophysiol. 121: 603-611, 2010.
  13. Qi, X., Okamoto, Y., Murakawa, T., Wang, F., Oyama, O., Ohkawa, R., Yoshioka, K., Du, W., Sugimoto, N., Yatomi, Y., Takuwa, N., and Takuwa, Y. Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK- eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. Eur. J. Pharmacol. 634: 121-131, 2010.
  14. Sakamoto, K., Nakata, H., Yumoto, M., and Kakigi, R. Effect of Mastication on Human Brain Activity. Anti-Aging Med. 7: 153-160, 2010.
  15. Suzuki-Inoue, K., Inoue, O., Ding, G., Nishimura, S., Hokamura, K., Eto, K., Kashiwagi, H., Tomiyama, Y., Yatomi, Y., Umemura, K., Shin, Y., Hirashima, M., and Ozaki, Y. Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J. Biol. Chem. 285: 24494-24507, 2010. “Paper of the Week
  16. Tejima, K., Masuzaki, R., Ikeda, H., Yoshida, H., Tateishi, R., Sugioka, Y., Kume, Y, Okano, T., Iwai, T., Gotoh, H., Katoh, S., Suzuki, A., Koike, Y., Yatomi, Y., Omata, M. and Koike, K. Thrombocytopenia is more severe in advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly. J. Gastroenterol. 45: 876-884, 2010. 
  17. Unuma, K., Shintani-Ishida, K., Tsushima, K., Shimosawa, T., Ueyama, T., Kuwahara, M., and Yoshida, K. Connexin-43 Redistribution and Gap Junction Activation During Forced Restraint Protects Against Sudden Arrhythmic Death in Rats. Circ. J.74:1087-1095, 2010.
  18. Unuma, K., Shintani-Ishida, K., Yahagi, N., Tsushima, K., Shimosawa,T., Ueyama, T., and Yoshida, K. Restraint stress induces coneexin-43 translocation via α-adrenoceptors in rat herat. Circ. J. 74: 2693-2701, 2010.
  19. Watanabe, K., Emoto, N., Sunohara, M., Kawakami, M., Kage, H., Nagase, T., Ohishi, N., and Takai, D. Treatment of PCR products with exonuclease I and heat-labile alkaline phosphatase improves the visibility of combined bisulfite restriction analysis. Biochem. Biophys. Res. Commun. 399: 422-424, 2010.
  20. Yamamoto, K., Imamura, H., Matsuyama, Y., Kume, Y., Ikeda, H., Norman, G.L., Shums, Z., Aoki, T., Hasegawa, K., Beck, Y., Sugawara, Y., and Kokudo, N. AFP, AFP-L3,DCP, and GP73 as markers for monitoring treatment response and recurrenceand as surrogate markers of clinicopathological variables of HCC. J. Gastroenterol. 45: 1272-1282, 2010.


  1. Sakamoto, K., Nakata, H., Yumoto, M., and Kakigi, R. Somatosensory processing of the tongue in humans. Front. Physio. 1:136. doi: 10.3389/fphys.2010.00136

International Conference Presentations

  1. Amemiya, K., Yumoto, M., and Yamasoba, T. Music syntactic processing in tonal and atonal melodiesD17th International Conference on Biomagnetism (BIOMAG 2010). 2010. 3. 28-4. 1. Dubrovnik, Croatia.
  2. Ando, M., Yumoto, M., Hara, K., Suzuki, Y., Yatomi, Y., and Matsuura, M. Effect of temporal prediction on auditory N1m responses. 29th International Congress of Clinical Neurophysiology (ICCN 2010). 2010. 10. 28-11. 1. Kobe, Japan.
  3. Fujii, S., Ito, S., Koike, K., Iwaki, S., Iwabuchi, K., Ohkawa, R., Mishima, Y., Yatomi, Y., and Furumoto, T. Hypoxia enhances S1P Release from adipocytes and provokes S1P-mediated insulin resistance by inducing TNF-α expression in adipose NKT cells. Scientific Session of the American Heart Association. 2010. 11. 14. Chicago, Illinois, USA.
  4. Igarashi, K., Nakamura, K., Aoki, J., and Yatomi, Y. Evaluation and clinical application of autotaxin immunoenzymetric assay using the automated immunoassay analyzer AIA-system. The 7th Cherry Blossom Symposium International Conference of Clinical Laboratory Automation and Robotics. 2010. 4. 16-17. Yokohama, Kanagawa, Japan.
  5. Okano, T., Terao, Y. Fukuda, H.,Emoto, M., Hanajima, R., Takenaka, K., Ikeda, H., Yatomi, Y., and Ugawa, Y. Gaze behabior when obserbing a ultrasonic diagnostic image. 29th International Congress of Clinical Neurophysiology. 2010.10.28-11.1. Kobe, Japan.
  6. Otsuka, A., Yumoto, M., Yamada, Y., and Kuriki, S. Neuromagnetic responses to musical chords: sensation of consonance and dissonance. 17th International Conference on Biomagnetism (BIOMAG 2010). 2010. 3. 28-4. 1. Dubrovnik, Croatia.
  7. Sugiura, T., Dohi, Y., Yamashita, S., Ohkawa, R., Yatomi, Y., Kimura, G., and Fujii, S.
    Sphingosine 1-phosphate is a bioactive lipid that confers high-density lipoprotein with vascular protection mediated by endothelium-dependent vasodilation. European Society of Cardiology Congress 2010. 8. 29. Stockholm, Sweden.
  8. Sugiura T., Dohi Y., Yamashita S., Ohte N., Mori C., Hirowatari Y., Ohkawa, R., Mishima Y., Yatomi Y., Kimura G., and Fujii S. Imbalance between plasma serotonin and Sphingosine 1-phosphate is a novel therapeutic target of statins in patients with early atherosclerosis. Scientific Session of the American Heart Association. 2010. 11. 15. Chicago, Illinois, USA.
  9. Yatomi, Y. Lipid mediators and atherothrombosis. XXth World Congress of the International Society for Heart Research. 2010. 5. 13-16. Kyoto, Japan.
  10. Yatomi, Y. Clinical laboratory medicine of lysophospholipid mediators. The 7th Seoul National University College of Medicine – The University of Tokyo Faculty of Medicine Joint Conference. 2010. 5. 28. Seoul, Korea.
  11. Yatomi, Y. Clinical introduction of plasma lysophosphatidic acid and serum autotaxin assays. Keystone Symposia: Bioactive Lipids: Biochemistry and Diseases. 2010. 6. 6-11. Kyoto, Japan.
  12. Yatomi, Y., Igarashi, K., Nakamura, K., Ohkawa, R., Masuda, A., Ikeda, H., and Aoki, J. Usefulness of the enzyme immunoassay of serum autotaxin reflecting the plasma lysophosphatidic acid level. Keystone Symposia: Bioactive Lipids: Biochemistry and Diseases. 2010. 6. 6-11. Kyoto, Japan.
  13. Yatomi, Y., Igarashi, K., Nakamura, K., Ohkawa, R., Masuda, A., Ikeda, H., and Aoki, J. Analysis of lysophospholipids and their related molecules: its introduction into clinical laboratory medicine. The 27th Naito Conference on “Membrane Dynamics and Lipid Biology [I]”. 2010. 6. 29-7.2. Sapporo, Hokkaido, Japan.
  14. Yokota, H. Clinical Laboratory in the world of change, Best Practice from The University of Tokyo Hospital. Associated Medical Technology of Thailand. 2010. 4. 21. Bangkok, Thailand.

Japanese papers cited in Pubmed

  1. Kaneko, M. [Active engagements in proffering for the most effective medical care--involvement of the department of clinical laboratory medicine]. Rinsho Byori 58: 925-934, 2010.
  2. Nakamura, K. and Yatomi, Y. [Lysophospholipids]. Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 7: 853-855, 2010.
  3. Okubo, S., Yokota, H., Ikeda, H., and Yatomi, Y. [Overview of ISO 15189 and accreditation with it]. Rinsho byori. The Japanese journal of clinical pathology 58: 676-684, 2010.
  4. Takai, D. [Aberrant methylation of circulating DNA for prediction of chemo-sensitivity of non-small cell lung cancer]. Gan to kagaku ryoho. Cancer & chemotherapy 37: 189-193, 2010.
  5. Yatomi, Y. [Clinical introduction of lysophosphatidic acid and autotaxin assays]. Rinsho byori. The Japanese journal of clinical pathology 58: 631-635, 2010.
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